Work

ALA-PDT used as a long-term management approach for refractory lichen sclerosus

Year: 2025

Type: article

Abstract: Significance Lichen sclerosus (LS) is a chronic and refractory inflammatory disease that can cause significant discomfort and deformities. The frequent recurrence of lesions underscores the need for effective long-term management strategies. Approach The patient received 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT). Results A young male patient with over a decade of refractory genital LS was treated with ALA-PDT following recurrence after surgery. After 13 sessions of ALA-PDT, the symptoms and lesions were well-controlled. However, lesions recurred when treatment was discontinued and switched to topical therapy. Subsequent courses of ALA-PDT repeatedly achieved lesion regression with great improvement of penile skin and no significant adverse effects observed. Conclusions ALA-PDT is a safe and effective long-term management option for male genital LS, providing sustained symptom control and lesion regression with minimal side effects.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104833

Authors: Yitao Qian, Lei Shi

Institutions: Fudan University, Huadong Hospital

Language: English

Topic: Genital Health and Disease

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610