Work

Efficacy and Mechanistic Insights into Indocyanine Green Photodynamic Therapy for Postoperative Keloids

Year: 2025

Type: article

Abstract: Our study evaluated the efficacy of surgery combined with indocyanine green (ICG) photodynamic therapy for keloids and explored its mechanisms through in vitro experiments. Patients with refractory keloids were randomized into a control group (surgery + corticosteroid injections) and a treatment group (additional ICG photodynamic therapy). Follow-ups were conducted over one year. ICG photodynamic therapy effectively reduced keloid recurrence with high safety and tolerability but limited efficacy. In vitro , keloid fibroblasts were treated with ICG photodynamic therapy to assess viability, migration, apoptosis, autophagy, and collagen formation. Photodynamic effects alone showed significant inhibition of cell viability, promotion of apoptosis and autophagy, and suppression of collagen formation at low drug concentrations. This informed an optimized clinical protocol that achieved improved outcomes, although further validation in controlled studies is required.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105066

Authors: Junyi Shao, Zhiming Li

Institution: First Affiliated Hospital of Wenzhou Medical University

Language: English

Topic: Dermatologic Treatments and Research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610