Work

Effect of photodynamic therapy with hypericin on the secretion of selected progression factors by colorectal cancer cells

Year: 2025

Type: article

Abstract: Significance The purpose of this study was to determine the role of HYP-PDT and its cytotoxic and immunomodulatory efficacy in the treatment of colorectal cancer, assessed on colon cancer cells. Approach Two colon cancer cell lines were used in this experiment: SW480 and SW620, that were treated with HYP-PDT . After HYP-PDT treatment, changes in the concentrations of GM-CSF, MFI, VCAM-1, ICAM-1 and IL-2, IL-4, IL6 were analyzed. Results For SW480 cells: after HYP-PDT, there was a marked decrease in the secretion of GM-CSF, MIF, VCAM-1 and ICAM-1. For SW620 cells after HYP-PDT: there was no effect on GM-CSF secretion; HYP-PDT inhibited the secretion of VCAM-1 and MIF and stimulated the secretion of ICAM-1 by the cells tested. The applied HYP-PDT showed no effect on the secretion of IL-2, IL-4 and IL-6 by the cell lines. Conclusions HYP-PDT shows cytotoxic and immunomodulatory potential on colon cancer cells.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104851