Work

Photodynamic Treatment of Lung Mucoepidermoid Carcinoma: A Case Report

Year: 2025

Type: article

Abstract: Significance Pulmonary mucoepidermoid carcinoma (PMEC) is a rare salivary gland-type tumor with no standard treatment. While photodynamic therapy (PDT) shows promise in early-stage central lung cancers, its role in PMEC remains underexplored. Approach We report a case of a 46-year-old male with low-grade PMEC of the left main bronchus. After initial bronchoscopic electrosnare resection, recurrence occurred 2 years later. The patient was treated with PDT, consisting of three consecutive daily sessions over three days using a 630 nm light source (0.9 W). Each treatment included two light exposures, with a total irradiation time of 600 seconds (540 J) for the first two sessions and 300 seconds (270 J) for the final session. Results PDT resulted in complete tumor response, with no residual tumor cells on histology. Follow-up over 38 months confirmed no recurrence. Conclusions This case demonstrates PDT as a minimally invasive therapy for early-stage PMEC, warranting further investigation.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105127

Authors: Qinyan Hong, Luoqi Yang, Heng Zou, Hongwu Wang

Institutions: Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610