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Radiotherapy May Exacerbate Anti‐Programmed Cell Death 1 Treatment-Induced Vitiligo: A Case Report

Year: 2025

Type: article

Abstract: Significance Immunotherapy with PD‐1 checkpoint inhibitors, combined with radiotherapy (RT), has shown potential for cancer treatment but is associated with immune-related adverse events (irAEs). This case highlights exacerbation of vitiligo as an irAE during combined PD-1 inhibitor and RT therapy. Approach A stage IIIb rectal cancer patient underwent PD‐1 inhibitor therapy combined with RT. Clinical outcomes and adverse effects were analyzed. Results Vitiligo lesions worsened post-RT, suggesting systemic immune activation. Remarkable repigmentation was observed after appropriate intervention, with a clinical complete response to cancer therapy. Conclusions The case suggests that irAEs, though challenging, may indicate favorable clinical responses.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104802

Authors: Chengqian Chen, Qihang Chang, Bo Wang, Zhen Zhang, Yaqi Wang, Xiuli Wang