Work

Effect of vaginal microbial infections on the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy for vaginal intraepithelial neoplasia

Year: 2025

Type: article

Abstract: Vaginal intraepithelial neoplasia (VAIN) is a precancerous condition with significant potential for malignant transformation. 5-Aminolevulinic acid photodynamic therapy (5-ALA-PDT) is considered to be a novel approach to treat VAIN. Recent studies have shown that an imbalance in the vaginal microbiota can affect the progression of VAIN. Thus, the effect of imbalanced microbiota on the efficacy of 5-ALA-PDT for treating VAIN needs to be determined. The findings of this study demonstrate that 5-ALA-PDT is a clinically effective and safe treatment for VAIN, and the vaginal microbiota’s status is a key factor affecting the efficacy of 5-ALA-PDT for VAIN.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104839

Author: Hongxia Yao

Institution: Shanghai First Maternity and Infant Hospital

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610