Work

Seamlessly Crossing Biological Barriers with a Low Molecular Weight Photosensitizer to Cure Aggressive Tumours with Photodynamic Therapy

Year: 2025

Type: article

Abstract: Significance We present LUZ51, a new fluorinated bacteriochlorin of relatively low molecular weight (595 Da), which is a highly phototoxic agent but still with a favourable safety profile1. LUZ51 is an effective candidate for PDT, especially for tumors characterized by high desmoplasia. Approach In vitro studies were conducted to evaluate uptake kinetics, phototoxicity and dark toxicity. The therapeutic effect of LUZ51-based PDT was evaluated in vivo in different models of cancer. Results LUZ51 is rapidly up-taken by cancer cells and has a phototoxicity in the low nanomolar region. In vivo, low-PDT regimen with LUZ51 significantly increases the overall survival of mice bearing tumors of moderate aggressiveness, such as subcutaneous CT26 tumors, as well as of highly aggressive tumors like 4T1 orthotopic tumors, which are characterized by desmoplasia and a high immunosuppressive environment.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105130

Author: Lígia C. Gomes-da-Silva

Institution: University of Coimbra

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610