Work

A case report of photodynamic therapy-assisted surgical treatment of recurrent oral squamous cell carcinoma

Year: 2025

Type: article

Abstract: Significance To report the efficacy of photodynamic therapy-assisted surgical treatment of recurrent oral squamous cell carcinoma. Approach A 71-year-old patient with left cheek squamous cell carcinoma had two recurrences in 3 years. Oral examination showed granular nodules on the surface of the left lower gingival buccal groove. The biopsy pathological diagnosis was "recurrence of left cheek squamous cell carcinomaafter surgery". Five photodynamic therapy sessions were conducted, during the period of waiting for surgical resection was performed. Results Postoperative pathological report: (left cheek) Severe dysplasia were showed in squamous epithelium on the surface of some areas, tending to local early canceration. The histological depth of infiltration (DOI) was about 1mm. No obvious recurrence was found in the follow-up. Conclusions Preoperative photodynamic therapy for oral squamous cell carcinoma can effectively control or reduce the lesion range, thereby reducing the extent of surgical resection and avoiding greater surgical trauma such as skin grafting.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104970

Authors: Xinyi Ni, Lei Zhang, Ying Han, Hongwei Liu

Institution: Peking University School and Hospital of Stomatology

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610