Work

The effect of local photodynamic therapy with 5-aminolevulinic acid in the treatment of multicentric squamous intraepithelial lesions in the female lower genital tract

Year: 2025

Type: article

Abstract: Background and Objective The detection rate of multicentric squamous intraepithelial lesions (SILs) in the female lower genital tract increased, recently. This study evaluates the efficacy and safety of topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating multicentric SILs. Methods A total of 101 patients with multisite SILs and underwent ALA-PDT were enrolled in this study. they were followed up at 3, 6, 9, and 12 months after the end of treatment, and every six months thereafter. Results At 6-month follow-up, the lesion complete remission (CR) rates in groups of cervical with vaginal SIL, cervical with vulvar SIL, vaginal with vulvar SIL, and cervical with vaginal and vulvar SIL were 78.3%, 89.5%, 100% and 85.7%, respectively. The HPV clearance rates were 53.6%, 53.6%, 50.0% and 28.6%, respectively. Conclusion ALA-PDT is a effective and safet reatment for multisite SILs. It removes the lesions while avoiding extensive damage to the female lower genital tract.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104875

Author: Mengzhen Zhang

Institution: First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610