Work

Regulation of Phototherapeutic Efficacy in Cutaneous Squamous Cell Carcinoma by Curcumin Nanosystems

Year: 2025

Type: article

Abstract: Significance Photodynamic therapy (PDT) is a non-invasive treatment that specifically targets tumor cells without damaging surrounding tissues, making it a promising approach for cutaneous squamous cell carcinoma (cSCC). Curcumin (Cur), a natural photodynamic agent, has limited therapeutic efficacy due to its poor water solubility and bioavailability. Enhancing its delivery could improve treatment outcomes. Methods A curcumin liposomal nanosystem (Lipo-Cur) was developed with an average size of 130-140 nm and a Zeta potential of -17 mV. Experiments included transdermal testing, CCK-8 assays, ROS detection, live/dead cell staining, EdU proliferation assays, Transwell and scratch tests, and Western blot analysis. Results Lipo-Cur significantly inhibited SCL-1 cell proliferation, with enhanced photodynamic therapy (PDT) effects under blue light, outperforming 5-ALA at low doses. It showed significant cytotoxicity and inhibitory effects on SCL-1 cells, modulating protein expression related to proliferation and migration. Conclusion Lipo-Cur demonstrates significant efficacy in PDT for SCC, offering a promising strategy for clinical treatment

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104947

Authors: Huiya Chen, Xiaoyu Zhao, Minyan Zhang, Yuhan Huang, Dan Xu

Institutions: Kunming Medical University, First Affiliated Hospital of Kunming Medical University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610