Work

Precision Conversion of Colorectal Cancer Lung Metastases: A Personalized Quadruplet Regimen Integrating Photodynamic Therapy with Targeted, Immunotherapy, and Chemotherapy

Year: 2025

Type: article

Abstract: Significance Colorectal cancer (CRC) has a high incidence and mortality rate, with lung metastasis being the second most common site. Current treatments have limited efficacy, and novel approaches are needed. Approach We report a case of a middle-aged female with CRC and lung metastasis treated with four cycles of PDT and five cycles of systemic therapy, including chemotherapy, targeted therapy, and immunotherapy. Results After treatment, the lung metastases showed cystic changes, and the primary tumor significantly regressed (TRG: AJCC 0, Becker 1a). Conclusions This multimodal therapy shows promise in CRC lung metastasis, offering new insights for treatment. This case is the first report on PDT combined with systemic therapy in this context.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105125

Authors: Qinying Han, Hao Chen

Institution: Lanzhou University Second Hospital

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610