Work

A case report of successful transformation of locally advanced colon cancer by placing a metal stent through colonostomy and anus reunion combined with PDT and systemic treatment

Year: 2025

Type: article

Abstract: Significance This study reports a case of a patient with locally advanced colon cancer (LACC) who achieved a no-evidence-of-disease (NED) state following combined photodynamic therapy (PDT) treatment. Methods The patient demonstrated poor tumor control with the XELOX regimen, with tumor growth observed at both the stoma site and the distal bypassed bowel. Dual-endoscopic PDT via the anus and stoma was performed, along with metallic stent placement. This was followed by targeted therapy and immunotherapy, leading to successful tumor resection. Results The combination of PDT and systemic therapy achieved a partial response (PR). The patient subsequently underwent radical resection of the colon cancer, achieving R0 resection with negative microscopic margins. The stoma was reversed during surgery, enabling the patient to achieve an NED state. Conclusion This PDT-based combined therapy significantly improved the patient’s quality of life, underscoring the clinical value of integrating PDT with targeted and immunotherapy as an effective strategy for managing LACC.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104844

Authors: Weigao Pu, Hao Chen

Institution: Lanzhou University Second Hospital

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610