Work

Nursing care of a patient with CARD9 gene deficiency treated with ALA-PDT for facial fungal infection ulcer

Year: 2025

Type: article

Abstract: Caspase recruitment domain protein 9 (CARD9) is an important signaling protein involved in the fungal immune process. In terms of treatment, adequate fungicide is often given in clinical practice, but the problems of drug resistance and hepatorenal toxicity of traditional fungicides make it an inevitable trend to seek new treatment methods. Photodynamic therapy (PDT) has the advantages of less trauma, faster healing, and better cosmetic effects. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is effective in the treatment of fungal skin infections and skin ulcers. We report a rare patient with a CARD9 gene defect who received two ALA-PDT treatments and nursing care for a facial Trichophyton rubrum ulcer. After two times of (ALA-PDT), the ulcer area was reduced. The ulcer healed up completely after a month and no recurrence was found in one year follow-up. The results showed that ALA-PDT had a significant therapeutic effect on fungal ulcers caused by gene defects.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104883