Work

Study on the effect and mechanism of Hemoporfin photodynamic inhibition on abnormal angiogenesis of port wine stain mediated by ATM-SerRS-VEGFA axis

Year: 2025

Type: article

Abstract: Significance This subject explore the molecular biological mechanism of photodynamic therapy for port wine stain and provide new research directions and strategies for the treatment of port wine stain. Results 1. HMME-PDT down-regulated the expression of VEGFA in HUVEC cells and inhibited the tube formation of HUVEC cells. 2. HMME-PDT up-regulated the expression of SerRS in HUVEC cells, downregulated the expression levels of ATM, p-ATM and VEGFA, and the downregulation of p-ATM was more obvious than that of ATM. 3. Compared with HMME-PDT group and tRA group, the inhibition of tube formation experiment of HUVEC cells in the combined group was more obvious, and the expression of VEGFA was down-regulated more obviously after combined treatment. Conclusion HMME-PDT can inhibit ATM phosphorylation, so that SerRS can exert its transcriptional inhibitory effect on VEGFA.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104872

Authors: Hongyan Lu, Hongyan Lu, Rong Huang, Sining Feng, Changxing Li, Kang Zeng

Institutions: Nanfang Hospital, Southern Medical University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610