Work

Title: Idealizing Sonodynamic: the coupling problem

Year: 2025

Type: article

Abstract: Photodynamic therapy (PDT) offers advantages such as non-invasiveness, non-ionizing properties, and shorter recovery times. However, its limited tissue penetration, particularly in pigmented areas like melanoma, remains a challenge. Sonodynamic therapy (SDT) addresses this limitation by using ultrasound, which penetrates deeper and is unaffected by tissue color. Combining PDT and SDT, known as sono-photo dynamic therapy (SPDT), could enhance therapeutic outcomes. This study explores methods to manipulate ultrasound beams using metallic cones to optimize focal depth and beam distribution. Variables such as cone diameter, height, curvature, and material were tested in a water tank, with hydrophones mapping ultrasound pressure in 2D. Results showed output diameter as the most significant factor for focal depth, while cone height had moderate effects. Curvature influenced beam shape, and material impacted overall performance. These findings support the development of SDT for precise clinical applications, enabling targeted energy delivery to treated regions.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104969

Authors: Jeongwung Seo, Iago Silva e Carvalho

Institution: Texas A&M University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610