Work

Methylene Blue-Mediated Photodynamic Therapy Combined with Corticosteroids for Erosive Oral Lichen Planus: Clinical and Antibacterial Effects

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Objective The aim of this study is to evaluate the clinical efficacy of methylene blue-mediated photodynamic therapy (MB-PDT) combined with local corticosteroids in the treatment of erosive oral lichen planus (E-OLP). Methods This study is a randomized controlled trial involving 40 patients diagnosed with erosive lichen planus. Patients were divided into two groups: the experimental group received methylene blue-mediated PDT combined with local corticosteroids, while the control group received only local corticosteroids. Both effectiveness and safety was assessed. Results The experimental group showed a higher clinical efficacy rate (94.7%) compared to the control group (90.4%) after 4 weeks of treatment. There was no statistical differences between the two groups(p>0.05). Conclusion MB-PDT may have potential application value in the treatment of E-OLP, but further studies with larger sample sizes and longer follow-up are needed to confirm these findings.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105147

Authors: Zhenyuan Wang, Guanhuan Du, Guoyao Tang

Institution: Shanghai Ninth People's Hospital

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610