Work

Simulation on Transdermal Drug Delivery for Photodynamic Therapy

Year: 2025

Type: article

Abstract: Significance Photodynamic therapy (PDT) is an effective treatment for skin conditions. Transdermal delivery in PDT allows direct targeting of skin lesions with reduced systemic exposure, making it a safer option. However, challenges like poor drug absorption and limited penetration depth limit its use. Addressing these issues and optimizing treatment parameters are key to improving transdermal PDT. Approach This study utilized COMSOL Multiphysics to simulate transdermal PDT, coupling oxygen and photosensitizer transport with light propagation to calculate ROS distribution and evaluate the efficacy. Results ROS concentration decreases with depth. Increasing 5-ALA ointment concentration from 10% to 20% improves superficial concentration but only increases effective depth by 4%. Reducing irradiance and extending exposure time improves photosensitizer distribution, expanding the treatment range by 21%. Conclusions The range of transdermal PDT is primarily influenced by photosensitizer distribution, determined by exposure time. Optimizing exposure time enhances efficacy, supporting its application in superficial skin disease.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104928

Authors: Yijia Li, Teng Jin, Xiaoming Hu, Qin Li

Institution: Beijing Institute of Technology

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610