Microstructural Brain White Matter Changes and Clinical Correlates in SPG3A
Year: 2025
Type: article
Study design: Observational Study
Abstract: Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Fig. S1. Heatmap of association between fractional anisotropy (FA) and clinical measures in SPG3A patients. Table S1. Clinical and genetic characteristics of SPG3A patients, including age, disease onset, SPRS score, phenotype, and identified ATL1 variants. Novel mutations are highlighted, and classification follows ACMG guidelines. Data S1. Supplementary methodology: Detailed description of MRI data acquisition parameters, preprocessing pipeline, region-of-interest extraction, and statistical procedures, including regression models, multiple comparison correction, and correlation analyses. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
DOI: 10.1002/mdc3.70426
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4416393052