Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Fetuses with ductal constriction (FDC), pulmonary hypertension and right ventricular overload after maternal exposure to PGE2 inhibitors-nonsteroidal anti-inflammatory drugs (NSAIDs) or polyphenols (PF)-have increased septum primum excursion index (SPEI), the ratio between maximal septum primum displacement and left atrial diameter. The objective of this study is to assess SPEI behavior and its correlation to mean pulmonary artery pressure (MPAP) after ductal constriction (DC) resolution. METHODS: Cohort study comparing SPEI and MPAP during and 2 weeks after DC reversal, following discontinuation of NSAIDs and PF. Criteria for DC diagnosis were systolic velocity >1.40 m/second, diastolic velocity >0.30 m/second, and pulsatility index <2.2. MPAP was estimated by Dabestani equation: MPAP = 90 - (0.62 × pulmonary artery acceleration time). STATISTICAL ANALYSIS: t-test and Pearson's correlation. RESULTS: Fifty-two pregnant women with FDC were evaluated. Following reversal, mean PI increased from 1.89 ± 0.20 to 2.54 ± 0.27 (p < .001), mean SPEI decreased from 0.75 ± 0.13 to 0.42 ± 0.12 (p < .001), and MPAP decreased from 70.33 ± 5.52 mmHg to 53.27 ± 6.68 mmHg (p < .001), with a significant correlation between MPAP and SPEI (r = 0.690). CONCLUSION: After resolution of fetal DC, the SPEI decreases, this effect being correlated with reduction in MPAP.
DOI: 10.1002/jum.70130
Authors: Paulo Zielinsky, Polyanna Henriques, Pedro Van Der Sand, Maria Antonia Saldanha, Gabriela Macelaro, Joana Nicoloso
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,100
Award: G3690646728
OpenAlex ID: W4416398196