Work

Modulation of host functions by bacterial serine/threonine protein kinase effector proteins

Year: 2025

Type: article

Abstract: Protein phosphorylation, one of the most ubiquitous and evolutionarily conserved posttranslational modifications, serves as a master regulator of cellular signaling networks. In host-pathogen interactions, bacterial subversion of phosphorylation-dependent signaling pathways has emerged as a pivotal mechanism of microbial pathogenesis. Notably, recent advances in eukaryotic-like serine/threonine protein kinase effector proteins have profoundly advanced our understanding of molecular pathogenesis through their ability to hijack host cell signaling. In this review, we will summarize the sophisticated strategies by which bacterial serine/threonine protein kinase effectors manipulate host phosphorylation networks to enhance virulence and promote infection.

Source: Journal of Biological Chemistry

DOI: 10.1016/j.jbc.2025.110950

Authors: Jinli Ge, Jiazhang Qiu

Institution: Jilin University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,430

Funders: National Natural Science Foundation of China, National Postdoctoral Program for Innovative Talents