Work

Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states

Year: 2025

Type: article

Abstract: neurons revealed dynamic shifts in ingestion-responsive activity between satiety states while the overall population activity remained stable. These findings reveal stable yet dynamic changes in network activity patterns between energy states, highlighting avenues for further investigation of the effects of obesity and GLP-1R agonists.

Source: iScience

DOI: 10.1016/j.isci.2025.114070

Authors: Rohan H. Savani, Le Wang, Yi Lu, Tiffany Le, Erin Park, Michael Yang, Zhiping P. Pang, Mark A. Rossi

Institution: Rutgers, The State University of New Jersey

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Robert Wood Johnson Foundation, Whitehall Foundation, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G243676485, G2988041300, G3410100967, G572141233, G6831780180, Cellular and genomic mechanisms of the impact of ethanol on human neural model, Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance

OpenAlex ID: W4416399512

FWCI: 0.704

Cites: 49

Cited by: 2

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