Work

D-ribose based organo catalyst for the sustainable synthesis of bioactive biscoumarins

Year: 2025

Type: article

Abstract: Herein, the reported work includes the design and synthesis of D-ribose containing DABCO (1,4-diazabicyclo[2.2.2]octane) sugar ionic liquid (DD-RSIL) via three steps and employed an organocatalyst for the synthesis of methylene or methine substituted biscoumarin analogues. The reaction involves the Knoevenagel condensation, proceeded by the Michael addition reaction. We demonstrated that the synthesized homogenous organocatalyst functioned effectively and could be reused through site-selective synthesis to produce a diverse array of bis-coumarin analogues with yields reaching up to 90% in a one-pot and metal-free process. We assessed the DD-RSIL as an efficient, environmentally friendly, and sustainable organocatalyst, exhibiting a high atom economy of 96.26%, an E-factor of 0.039, and 100% carbon efficiency. A total of 31 derivatives were synthesized with yields reaching up to 90% within 2 hours of stirring at 70 °C under mild reaction conditions. A variety of biscoumarin derivatives were produced utilizing substituted aliphatic, aromatic, and heterocyclic aldehydes. The capacity for scalability is another significant benefit of this methodology.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2025.102882

Authors: Pavani Yasam, Rajagopal Desikan

Institution: Vellore Institute of Technology University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $1,870