Allergy-unrelated eosinophil activation in the peripheral blood of children with neurodevelopmental disorders
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Neurodevelopmental disorders (NDDs) are increasingly associated with immune dysregulation, but eosinophil activation independent of allergic diseases remains unexplored in this population. Methods Peripheral-blood eosinophil cationic protein (ECP) mRNA expression was quantified in 55 children with NDDs—including developmental delay (DD), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), communication disorder, and tic disorder—and 32 typically developing controls. Participants with allergies or recent infections were excluded. Results The NDDs group exhibited significantly elevated ECP mRNA levels compared to controls, with median values of 165.87 copies/μL vs. 56.92 copies/μL ( p < 0.001). Subgroup analyses confirmed increases in DD ( p = 0.020), ASD ( p = 0.002), and ADHD ( p = 0.014), though no inter-subgroup differences were observed. Multivariate analysis identified NDDs as an independent predictor of ECP elevation ( p = 0.048). Two high-ECP subjects harbored copy number variants affecting neuroimmune genes ADA and LAT . No correlations emerged between ECP levels and clinical behavioral scores. Conclusion These findings establish a novel association between non-allergic eosinophil activation and NDDs, implicating neuroimmune crosstalk in disease pathogenesis and supporting ECP as a potential biomarker.
Source: Frontiers in Neurology
Authors: Wenjing Ji, Muhan Li, Chenlu Yang, Yuanyuan Lu, Aimin Liang
Institutions: Capital Medical University, Beijing Children’s Hospital
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416404859