Work

A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care

Year: 2025

Type: article

Abstract: Objective: To study the associations of B cell lymphoma 6 (BCL6) in endometrial endometriosis, and to determine a practice's experience testing BCL6 in patients with recurrent pregnancy loss/recurrent implantation failure (RPL/RIF). Design: Retrospective chart review. Subjects: Endometrial samples were collected at the time of laparoscopy from 19 reproductive-aged individuals with known stage II-IV endometriosis. Endometrium biopsies were also collected from eight healthy controls, at a single academic center. Exposure: 1.4), postbiopsy interventions on the basis of the positive result were then compared with positive patients who did not receive treatment for their positive result of BCL6 test. Main Outcome Measures: value of <.05 was considered statistically significant. Results: result. Conclusion: The relationship between BCL6 and endometriosis may not be the golden solution to a single marker focus for testing, or for subsequent therapy planning among infertility patients. Clinicians should be cautious in using single marker testing for diagnosing and treating endometriosis in patients without strong additional therapeutic evidence.

Source: F&S Reports

DOI: 10.1016/j.xfre.2025.11.005