Work

Relating corynebacterial cell envelope layers to its biochemical and physical properties

Year: 2025

Type: article

Abstract: as a model to examine how disruptions in different layers of the cell envelope, specifically the arabinogalactan and mycolic acid layers, influence both biochemical and biophysical properties. We assessed surface hydrophobicity, antibiotic sensitivity, and lipid composition, and complemented these assays with atomic force microscopy to examine structural changes. Our analysis of multiple cell wall mutants suggests that a division of labour occurs among the layers of the corynebacterial envelope, where each layer contributes to distinct, but complementary functions to overall cell wall physiology.

Source: The Cell Surface

DOI: 10.1016/j.tcsw.2025.100162

Authors: Mamata Modak, Uchenna Watson Waturuocha, Deepak Kumar Saini, Apoorva Bhatt, Gurdyal S. Besra

Institutions: University of Birmingham, Indian Institute of Science Bangalore

Language: English

Topic: Diphtheria, Corynebacterium, and Tetanus

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,530

Funders: UK-India Education and Research Initiative, Darwin Trust of Edinburgh, Medical Research Council, Medical Research Foundation