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Natural Product-Based Discovery of Antibacterial Agents from Sophora tomentosa L. to Tackle Drug Resistance

Year: 2025

Type: conference-paper

Abstract: The rapid emergence of antimicrobial resistance (AMR) threatens global health by reducing the effectiveness of current antibiotics. Natural products remain an essential source of structurally diverse compounds with therapeutic potential. This study’s methanolic extracts of Sophora tomentosa L., a leguminous plant with traditional medicinal uses, were fractionated by liquid–liquid extraction and column chromatography. Dichloromethane and ethyl acetate fractions from leaves and seeds exhibited antibacterial activity against Kocuria rhizophila and Bacillus cereus. GC–MS profiling revealed alkaloids (e.g., matrine), flavonoids (e.g., catechin), phthalic acid derivatives, and fatty acids, supporting the potential of S. tomentosa as a source of novel antibacterial agents.

DOI: 10.3390/blsf2025053001

Authors: Supattra Poeaim, Patcharanun Laowklang, Narumon Tangthirasunun, Thanarak Chantaraprasit

Institution: King Mongkut's Institute of Technology Ladkrabang

Language: English

Topic: Bioactive natural compounds

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Funder: National Research Council of Thailand

OpenAlex ID: W4416407417

FWCI:

Cites: 8

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