Inside Front Cover: Click‐Cyclized Cell Penetrating Peptides Containing Hydrophobic Proline Derivatives for Efficient Intracellular Delivery (Angew. Chem. Int. Ed. 50/2025)
Year: 2025
Type: paratext
Abstract: EGFP linked to a click-cyclized cell penetrating peptide that attach itself to the cell membrane and internalize into the cell, while carrying the EGFP as a cargo. The best CPP was selected from a designed library of linear and click cyclized D-peptides having four arginines and a naphthyl group. As indicated by membrane curvature the cell penetration occurs by a dynamin dependent endocytosis mechanism. The cells were healthy at all concentrations investigated indicating low or no toxicity. More in the Research Article (e202504862) by Morten Meldal and co-workers.
Institution: University of Copenhagen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4416407477
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