Cross sections of $$^{147-149}$$Sm($$^{6}$$Li,x) reactions for the production of $$^{149}$$Tb for targeted alpha therapy
Year: 2025
Type: article
Abstract: Terbium-149g ([Formula: see text] = 4.12 h) is of particular interest for targeted alpha therapy cancer treatment due to its ability to decay via both alpha and positron emission, making it a potential theranostic nuclide. Due to many challenges facing its production, there are limited facilities worldwide that have demonstrated the ability to produce this nuclide in quantities sufficient for medical research. Since the Cyclotron Institute at Texas A&M University is a specialized accelerator facility capable of accelerating a wide variety of ions, we are investigating production pathway options. One of the major challenges facing its production is the known co-production of the excited isomeric state, [Formula: see text]Tb ([Formula: see text] = 4.1 min). However, this state does not decay to the ground state of [Formula: see text]Tb, negating any potential contribution to its yield. Due to its short-half life, the cross section for the population of this state has never been measured. After calculating several potential reaction yields using predictive models, the reactions of [Formula: see text]Sm([Formula: see text]Li,xn)[Formula: see text]Tb were identified as candidates. Lithium-6 beams of varied energies between 45-65 MeV were impinged on enriched [Formula: see text]Sm, [Formula: see text]Sm, and [Formula: see text]Sm targets at the Cyclotron Institute at Texas A&M University, and the reaction products were measured immediately following irradiation using high-purity germanium detectors, enabling detection of both [Formula: see text]Tb and [Formula: see text]Tb. Cross sections for all nuclides produced in sufficient activity in these reactions were also measured and reported here. We conclude that the population of [Formula: see text]Tb is much preferred over population of the ground state for these [Formula: see text]Li-induced reactions, and it is necessary to explore other options for [Formula: see text]Tb production.
Source: Scientific Reports
Authors: Laura A. Bills, Alan B. McIntosh, Jonathan T. Morrell, Philip Adsley, Austin D. Abbott, Diana Carrasco Rojas, Jeremias Garcia-Duarte, Matthew D. Gott, Kris Hagel, Travis Hankins, Jason T. Harke, Bryan M. Harvey, Richard O. Hughes, Lauren A. McIntosh, Yonatan Mishnayot, Connor Mohs, Gabriela A. Picayo, Madison Reuter, Robert Rider, John Santucci, Sophia Sauceda, Maxwell Sorensen, Alexandra Tabacaru, Aaron S. Tamashiro, Evgeny E. Tereshatov, David Thomas, Zachary Tobin, C. Etienne Vermeulen, Benjamin Wellons, Sherry J. Yennello
Language: English
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G1088636562, G1180767462, G14554683, 211 AT PRODUCTION AT TEXAS A&M UNIVERSITY CYCLOTRON INSTITUTE, G2145270357, G222768804, G2812149348, TEXAS A&M UNIVERSITY
CENTER OF EXCELLENCE IN NUCLEAR TRAINING AND UNIVERSITY BASED RESEARCH (CENTAUR), NEW AWARD - "CYCLOTRON BASED NUCLEAR SCIENCE" PI - JOSEPH B.NATOWITZ, TEXAS A&M UNIVERSITY CYCLOTRON INSTITUTE RESEARCH PLAN, NEW AWARD - "CYCLOTRON BASED NUCLEAR SCIENCE" PI - JOSEPH B.NATOWITZ, GRAPHENE BACKING FOR RADIOISOTOPE TARGETS, TEXAS A&M UNIVERSITY CYCLOTRON INSTITUTE RESEARCH PLAN, G5531411435, G574795485, G6750061500, HIPPO: HORIZON-BROADENING ISOTOPE PRODUCTION PIPELINE OPPORTUNITIES, G8195599115
OpenAlex ID: W4416409903