Work

Prolonged intermittent hypoxia accelerates cardiovascular aging and mortality: insights from a murine model of OSA

Year: 2025

Type: article

Abstract: Obstructive sleep apnea (OSA) accelerates cardiovascular aging through intermittent hypoxia (IH). We exposed mice to 22 months of IH, modeling lifelong OSA. Compared to controls, IH mice exhibited higher mortality, elevated blood pressure, impaired systolic and diastolic function, vascular stiffening, reduced coronary reserve, and ECG abnormalities. These findings suggest that chronic IH significantly exacerbates cardiovascular decline with aging, underscoring the importance of early OSA diagnosis and intervention.

Source: npj Aging

DOI: 10.1038/s41514-025-00283-4

Authors: Mohammad Badran, Clementine Puech, David Gozal

Institutions: University of Missouri, Marshall University

Language: English

Topic: Obstructive Sleep Apnea Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,690