Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study
Year: 2025
Type: article
Abstract: The entorhinal cortex (EC) is known to play important roles in spatial cognition of human behaviors. However, the functional contributions and the lateralization of EC are not well known. This paper proposed a new paradigm by employing non-invasive stimulation - Temporal interference (TI) - of human EC in left or right hemisphere under path integration (PI) tasks of sensory-driven and abstract processing. Five metrics were introduced to evaluate PI performance, with results revealing significant improvements after EC stimulation. Moreover, the left EC modulation achieved more enhanced performances of abstract processing, whereas the modulation of the right EC had better improvements in the sensory-driven condition. The results indicated that functional roles may differ in left and right EC under PI tasks. This study provided valuable insights into hemispheric specialization within EC and suggested potential pathways for developing early intervention strategies through the non-invasive modulation of EC. This study shows that temporal interference stimulation of the entorhinal cortex can enhance path integration abilities of human, with stimulation at left and right hemisphere enhancing different aspects of spatial cognition.
Source: Nature Communications
Authors: Haiyan Zhao, Binglei Zhao, Jiajun He, Manhua Liu
Institutions: Shanghai Jiao Tong University, Johns Hopkins University
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
OpenAlex ID: W4416410557