Work

Adapting international evidence-based guidelines to local challenges: A Lebanese perspective on the latest American Thoracic Society and Infectious Diseases Society of America (ATS/IDSA) community-acquired pneumonia antibacterial therapy recommendations

Year: 2025

Type: article

Abstract: • Rising antimicrobial resistance in Lebanon necessitates tailored CAP management strategies. • 2025 Lebanese recommendations adapt IDSA/ATS guidelines to local AMR patterns. • Empiric therapy is stratified by CAP severity, care setting, and pathogen risk factors. • Recommendations emphasize antibiotic de-escalation, follow-up, and stewardship principles. • Adapted algorithms aim to optimize patient outcomes and preserve antibiotic efficacy. Community-acquired pneumonia (CAP) remains a major global health concern, particularly in regions with rising antimicrobial resistance (AMR). In Lebanon, increasing resistance among respiratory pathogens complicates management, limiting treatment options and worsening clinical and economic outcomes. This expert panel review assessed recent national AMR data to adapt CAP treatment recommendations to the Lebanese context. The 2019 ATS/IDSA guidelines and their 2025 update were reviewed; while most recommendations were retained, empiric antibiotic choices were adjusted for key pathogens based on local resistance patterns. The proposed management algorithm stratifies patients by disease severity, care setting, and AMR risk, integrating pathogen-specific risk factors into clinical decisions. By contextualizing international guidance to local epidemiology and healthcare infrastructure, these recommendations aim to optimize targeted therapy, support antimicrobial stewardship, and preserve antibiotic efficacy in Lebanon’s evolving resistance landscape.

Source: Journal of Global Antimicrobial Resistance

DOI: 10.1016/j.jgar.2025.11.005