Work

Atypical bone and synovial metastases from colorectal adenocarcinoma: A case report

Year: 2025

Type: article

Abstract: Colorectal cancer (CRC) is a prevalent malignancy globally, ranking third in incidence and second in cancer-specific mortality. Despite advancements in diagnosis and treatment, the incidence of CRC, especially in younger individuals and developing countries, is rising. We present a unique case of a woman initially diagnosed with cecal adenocarcinoma who developed metachronous atypical bone and soft tissue metastases, including involvement of the left knee synovium. This case underscores the diagnostic and therapeutic complexities in managing CRC patients with atypical metastatic disease. The patient underwent various treatments, including surgery, chemotherapy, radiotherapy, and targeted therapy, exhibiting mixed responses and prolonged survival compared to the typical prognosis. This case highlights the importance of clinical presentation in identifying unusual metastatic presentations in CRC patients and the need for individualised treatment approaches.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.10.016

Authors: Giordana Di Mauro, Rosa Berenato, Carmine Fazzari, Anthea Miller, Francesco Buemi

Institutions: University of Messina, Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600