Work

TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndrome

Year: 2025

Type: article

Abstract: protected mice from hyperinflammatory response and organ damage in MAS, and mechanistically, alleviated NLRP3 inflammasome activation in macrophages. Our study reveals mechanisms of FOXO3 in facilitating AOSD-MAS development and identifies the critical role of FOXO3 in the self-negative regulation of inflammation in AOSD through suppression by TLR9 signaling.

Source: iScience

DOI: 10.1016/j.isci.2025.114098

Authors: Mengyan Wang, Yuning Ma, Jianfen Meng, Chengde Yang, Dehao Zhu, Xia Chen, Longfang Chen, Yu Xiao, Da Yi, Hui Shi, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Fan Wang, Jialin Teng, Ping Hu, Jinchao Jia, Qiongyi Hu

Institutions: Shanghai Jiao Tong University, Ruijin Hospital, Guangzhou Laboratory, Guangzhou Medical University

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Shanghai Lingjun Program, National Natural Science Foundation of China, Shanghai Jiao Tong University, Postdoctoral Research Foundation of China

Awards: G1024251615, G1357559934, G1358883641, G1384256600, G52070960, G571985225, G8851518572

OpenAlex ID: W4416411166

FWCI: 0.636

Cites: 44

Cited by: 1

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