Year: 2025
Type: article
Abstract: BACKGROUND: Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc. OBJECTIVES: As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against Nitroxoline using broth microdilution. METHODS: Overall, 13 Aspergillus isolates were tested according to the EUCAST guidance document (Guinea et al. EUCAST, def. doc. 9.4, 2022) including two genetically proven Azole-resistant strains. RESULTS: was 0.5 mg/L. CONCLUSIONS: These results correspond to excellent in vitro activity against Aspergillus spp.
Source: Mycoses
DOI: 10.1111/myc.70131
Institutions: University of Cologne, University Hospital Cologne, German Center for Infection Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI), University Hospital Regensburg, Klinikum St. Marien Amberg
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,780
Award: G7960612885
OpenAlex ID: W4416411613