Autonomic function testing and symptom severity in patients with suspected mast cell activation disorders
Year: 2025
Type: article
Study design: Observational Study
Abstract: We assessed both objective and subjective measures of autonomic severity in patients with formally classified mast cell activation disorder (MCAD), hereditary alpha tryptasemia (HaT), and systemic mastocytosis. In all subjects, autonomic disease severity was objectively mild but subjectively moderate to severe. The presence of MCAD did not yield consistent differences on subjective or objective severity measures, although HaT did associate with lower objective (but not subjective) severity measures. In conclusion, assessment of MCAD and related disorders can be conducted using formal classification criteria, and in those with suspected dysautonomia, the workup should incorporate objective and subjective measures of dysautonomia.
Source: Autonomic Neuroscience
Authors: Amro M. Stino, Jodi Nelson, Olivia Gutgsell, Ahmed Eldokla, Jasmine Liu, Cem Akin
Institutions: University of Michigan, Michigan Medicine
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
OpenAlex ID: W4416412741