Work

The role of exosomes as oligonucleotide delivery system for managing α-synuclein in Parkinson’s disease: A systematic review of in vivo studies

Year: 2025

Type: review

Abstract: studies relevant to the subject. Of 904 initial records, five eligible studies were selected. Three utilized transgenic mouse models and two used induced models to simulate PD. All reported a reduction in α-syn aggregation in the midbrain-particularly in the substantia nigra-following treatment with exosome-delivered oligonucleotides. This reduction was associated with decreased neuronal death and improved motor function. No significant toxicity or immune response was reported. Exosome-mediated oligonucleotide delivery appears to be a promising approach to reduce α-syn aggregation, protect dopaminergic neurons, and improve motor symptoms in animal models of PD.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102776

Authors: Soodeh Salarpour, Fatemeh Dourandish, Arsalan Salajegheh, Sara Hashemi

Institution: Kerman University of Medical Sciences

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900