Year: 2025
Type: article
Abstract: Two new cytochalasans (1–2), along with eight known ones (3–10) were isolated from sponge-derived Aspergillus sp. SCSIO 41044. The planar structures of 1–2 were elucidated through extensive spectroscopic analyses and their absolute configurations determined by modified Mosher’s methods. Biological evaluation revealed that 5, 7, and 8 showed potent cytotoxicity against small cell lung cancers H446 and H1048, with IC50 values ranging from 0.0441 to 1.61 μM.
Source: Molecules
Authors: Xiaoyan Pang, Ini Wong, Qinlin Cao, Junfeng Wang, Xuefeng Zhou, Bin Yang, Junjian Wang, Hong Wang, Yonghong Liu
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,258
Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Institute of Oceanology, Chinese Academy of Sciences, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province
OpenAlex ID: W4416413046