Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit
Year: 2025
Type: article
Abstract: Human spaceflight is advancing toward sustainable exploration through initiatives like NASA's Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome-integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.
Source: npj Microgravity
Authors: Damian M. Bailey, Dieter Blottner, Hanns-Christian Gunga, Stefan Schneider, Virginia Wotring, Sarah Baatout, Marco Durante, Rik H. G. Olde Engberink, Nandu Goswami, Martina Heer, Anna-Maria Liphardt, Monica Monici, Francesco Pagnini, Claudia Stern, Jan-Bernd Stukenborg, Tobias Weber, Laurence Vico, Olivier White, Angelique van Ombergen, Alexander Choukér
Institutions: University of South Wales, Humboldt-Universität zu Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin, German Sport University Cologne, International Space University, Baylor College of Medicine, Ghent University, Belgian Nuclear Research Centre, GSI Helmholtz Centre for Heavy Ion Research, Technische Universität Darmstadt, University of Naples Federico II, Amsterdam UMC Location University of Amsterdam, Amsterdam Cardiovascular Sciences, Medical University of Graz, Mohammed Bin Rashid University of Medicine and Health Sciences, University of Bonn, IU International University of Applied Sciences, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, University of Florence, Università Cattolica del Sacro Cuore, Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR), Uppsala University, Karolinska University Hospital, Karolinska Institutet, Northumbria University, European Astronaut Centre, Inserm, Mines Saint-Étienne, Université Jean Monnet, Université de Bourgogne, Cognition, Action, and Sensorimotor Plasticity, University of Antwerp, European Space Agency, LMU Klinikum, Ludwig-Maximilians-Universität München
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Funders: Centre national d'études spatiales, University of Pennsylvania, Pennsylvania State University, European Space Agency, Royal Society, Bundesministerium für Bildung und Forschung, Belgian Federal Science Policy Office, Centre National d’Etudes Spatiales, Agenzia Spaziale Italiana, Institut Polaire Français Paul Emile Victor
OpenAlex ID: W4416413143