Work

Report of a case of nasal-type extranodal NK/T-cell lymphoma with ciliary body involvement and literature review of interleukin-10 and interleukin-6 in intraocular T-cell lymphoma

Year: 2025

Type: article

Abstract: To present a presumed case of NK/T-cell lymphoma with ciliary body involvement, emphasizing key clinical findings and diagnostic testing that facilitated differentiation from anterior uveitis. Retrospective case report and review of the literature. A 47-year-old man with a history of nasal-type extranodal NK/T-cell lymphoma (ENKL) presented with cloudy vision in the left eye and was initially diagnosed with anterior uveitis. Work-up initially included aqueous interleukin-10 (IL-10) and interleukin-6 (IL-6) ratio determination, and later B-scan and ultrasound biomicroscopy (UBM). The IL-10/IL-6 ratio was less than 1, but ultrasound imaging revealed peripheral subretinal fluid and ciliary body thickening. The patient underwent five cycles of intravitreal methotrexate for presumed uveal lymphoma involving the ciliary body with pseudo-keratic precipitates before a nasal biopsy confirmed recurrent ENKL. A review of the literature regarding IL-10/IL-6 ratios showed that 71% of published cases of intraocular T-cell lymphoma had ratios less than 1. ENKL, nasal type, is an aggressive and uncommon disease, and its ocular involvement, though infrequent, can resemble anterior uveitis. The IL-10/IL-6 ratio is of limited value in the diagnosis of T-cell lymphoma affecting intraocular structures. This case highlights the critical role of UBM in identifying ciliary body involvement of intraocular malignancies. • Overlapping clinical presentations between extranodal NK/T-cell lymphoma and anterior uveitis can complicate diagnosis and delay treatment. • Ultrasound biomicroscopy is an effective tool to determine ciliary body involvement in extranodal NK/T-cell lymphoma. • There are limitations using the interleukin-10 to interleukin-6 ratio as a diagnostic tool for T-cell lymphoma within the eye.

Source: American Journal of Ophthalmology Case Reports

DOI: 10.1016/j.ajoc.2025.102483

Authors: Madeline S. Louie, Nathan A. Brice, Edmund Tsui, Judy L. Chen, Colin A. McCannel

Institution: University of California, Los Angeles

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590