Work

The effect of TPOAb on pregnancy outcomes among people with polycystic ovary syndrome with euthyroidism undergoing in vitro fertilization

Year: 2025

Type: article

Abstract: Background PCOS is a complex endocrine disorder affecting fertility. PCOS patients combined with TAI have a higher risk of reproductive complications. The interplay between TAI and PCOS in the context of ART outcomes represents an unsolved problem. Therefore, the relationship between TPOAb and embryologic or pregnancy outcomes of IVF/ICSI in a cohort of infertile female patients diagnosed PCOS with euthyroidism should be evaluated. Methods A retrospective cohort study is conducted. After selected with standard diagnostic code, strict inclusion and exclusion criteria and 1:4 PSM, 62 PCOS patients with TPOAb positive matched with 216 TPOAb negative PCOS patients from October 2014 to September 2022 are included in the study. The primary outcomes are live birth rate and clinical pregnancy rate, and secondary outcomes include other pregnancy-related outcomes and laboratory parameters related to embryologic quality. Results In the TPOAb-positive group, fertilization rate, 2PN fertilization rate, and 2PN cleavage rate are significantly higher than those in the TPOAb-negative group ( P < 0.05). However, TPOAb levels are not significantly associated with those embryo parameters in two groups after adjusting for propensity scores ( P > 0.05). Then, we show that there are no correlation between TPOAb and pregnancy outcomes in TPOAb-positive and TPOAb-negative PCOS populations ( P > 0.05). Conclusions TPOAb is not a risk factor for embryonic or pregnancy outcomes in PCOS patients with euthyroidism undergoing IVF/ICSI. TPOAb-positive indicator should not be paid too much attention, and does not need to be overtreated for PCOS patients with euthyroidism undergoing IVF/ICSI.

Source: Communications Medicine

DOI: 10.1038/s43856-025-01173-2