ELOC(TCEB1)-mutated renal cell carcinoma: a case report and clinicopathological analysis
Year: 2025
Type: article
Study design: Case Report
Abstract: ELOC (also referred to as TCEB1 )-mutated renal cell carcinoma ( ELOC -mutated RCC) is a rare, molecularly defined RCC newly incorporated into the 2022 5th Edition WHO Classification of Tumours of the Urinary and Male Genital Organs. It exhibits a broad histomorphological spectrum with overlapping features with clear cell RCC, posing diagnostic challenges and potential for misdiagnosis if not considered. This report presents a case initially diagnosed as CK7-positive RCC with fibromyomatous stroma (RCC-FMS). Next-generation sequencing (NGS) revealed a ELOC p.Y79C gene mutation in tumor cells, leading to the definitive diagnosis of ELOC -mutated RCC. Enhancing awareness of this rare tumor is crucial for improving diagnostic accuracy.
Source: Frontiers in Oncology
Institutions: Ningbo No. 2 Hospital, Hangzhou Cancer Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416415536