Immunological role of IL-25 on gut-dwelling helminths
Year: 2025
Type: article
Abstract: Interleukin-25 (IL-25) is a crucial cytokine in coordinating type 2 immunity against gut-dwelling helminths. IL-25 is produced by a variety of cells, including epithelial and immune cells, and primarily stimulates Th2-type immune responses characterized by the release of IL-13, IL-5, and IL-4, which play a vital role in eosinophilia induction, goblet cell hyperplasia, and IgE synthesis. This review critically examines IL-25's role in maintaining intestinal barrier integrity and modulating regulatory immune responses. This review addresses how IL-25 integrates signals from the epithelial interface, immune cells, and gut microbiota to calibrate appropriate host defense while preventing pathological inflammation. Furthermore, this paper presents recent evidence supporting IL-25's therapeutic potential, both as a potential adjuvant therapy to enhance parasite clearance and as a modulator of inflammatory conditions where type 2 immunity proves deficient.
Source: Infection Genetics and Evolution
Authors: Gashaw Azanaw Amare, Yenesew Mihret Wondmagegn, Adane Adugna, Desalegn Abebaw, Abateneh Melkamu, Habtamu Belew, Zigale Hibstu Teffera, Mamaru Getinet, Mohammed Jemal, Temesgen Baylie, Deresse Sinamaw Asmare, Abebe Yenesew, Abebe Fenta, Mesafint Woreket, Abebaw Setegn, Birhanu Malede
Institutions: Debre Markos University, University of Gondar, Injibara University
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,730
OpenAlex ID: W4416418242