Work

Non-Histone Lysine Modifications in Tumor Microenvironment: Mechanisms and Therapeutic Opportunities

Year: 2025

Type: article

Abstract: Post-translational modifications (PTMs) on protein lysine residues, including lactylation, methylation, acetylation, ubiquitination, and succinylation, serve as critical regulators in tumorigenesis and progression. Histone PTMs participate in tumor development by modulating chromatin structure and regulating gene expression. Notably, accumulating evidence reveals that PTMs target extensive non-histone substrates. These modifications occurring on non-histone proteins also contribute to tumor-associated biological processes. In this review, we systematically summarize the impact of non-histone PTMs on tumor and the tumor immune microenvironment (TIME). Additionally, we discuss crosstalk between distinct PTMs, which complicates the regulatory mechanisms of protein function. An in-depth research on PTMs in tumors holds new insights for exploring promising clinical therapeutic strategies.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms262211229

Authors: Kai Sun, Shuying Xiao, Qibo Huang, Suhang Zhang, Qilin Li, Chuanyu Hu

Institutions: Tongji Hospital, Huazhong University of Science and Technology

Language: English

Topic: Cancer-related gene regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499