Work

Impact of vitamin D insufficiency on cardiac function in patients with systemic sclerosis

Year: 2025

Type: article

Abstract: This is a commentary on a recent research paper about the link between vitamin D deficiency and cardiovascular compromise in systemic sclerosis (SSc) patients. The study is a sound report and contributes significantly to knowledge about the cardiovascular impact of vitamin D deficiency. Strengths are adherence to ethical and diagnostic guidelines throughout, thorough cardiopulmonary characterization, and complete data acquisition. However, the absence of dietary and adiposity data (for example, energy intake), the possibility of a selection bias, as well as assumptions on parametrization for categorical variables could all introduce some limitations to our findings.Nevertheless, despite these limitations, the study indeed adds significant value to our knowledge on how vitamin D status interplays with cardiac remodeling amongst individuals with SSc and highlights the need for more mechanistic/intervention work.

Source: International Journal of Cardiology Cardiovascular Risk and Prevention

DOI: 10.1016/j.ijcrp.2025.200546

Authors: Susan Darroudi, Leila Bigdelu

Institutions: University of Modena and Reggio Emilia, Mashhad University of Medical Sciences

Language: English

Topic: Systemic Sclerosis and Related Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,710