Work

Impact of dexamethasone on postoperative inflammatory markers and recovery outcomes in elderly patients undergoing open lumbar surgery

Year: 2025

Type: article

Abstract: < 0.001; median difference 52.5 mL, 95% CI 32.5-80.0). Patients receiving dexamethasone showed lower early pain scores, improved recovery, and attenuated inflammatory markers. Transient postoperative hyperglycemia occurred without an increase in infections. These findings support a single preoperative dose of dexamethasone mitigated early inflammation and enhanced recovery in older adults after lumbar spine surgery.

Source: iScience

DOI: 10.1016/j.isci.2025.114133