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Probiotic DNA epigenetically modulates KDM4A degradation to mitigate airway allergy

Year: 2025

Type: article

Abstract: T cell mice showed spontaneous airway Th2 polarization (AA-like pathology). AA mice had impaired Tr1 immunosuppression, lower KDM4A at Il-10 promoter (correlating with reduced IL-10/Tr1 suppression), increased Il-10 promoter H3K9me3/hypermethylation, and reduced USP14. Probiotic DNA elevated USP14, restored KDM4A, enhanced Tr1 function, and reduced AA responses. In conclusion, reduced Il-10-promoter KDM4A drives Tr1 dysfunction in AA; probiotic DNA mitigates AA via USP14 upregulation (restoring KDM4A/Tr1 function), a potential therapeutic target.

Source: iScience

DOI: 10.1016/j.isci.2025.114065