Work

Additive-Controlled Divergent Synthesis of Amides and Ketones via Ni/Photoredox-Catalyzed Deoxygenative Functionalization of Alcohols

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Amides and ketones are essential carbonyl compounds with widespread applications in pharmaceuticals, materials science, and synthetic chemistry. Herein, we present a Ni/photoredox dual-catalyzed strategy for the divergent synthesis of amides and ketones from isocyanates and alcohols. This transformation is facilitated by N -heterocyclic carbene (NHC)-mediated activation of alcohols and is selectively controlled by the choice of additive: NaOAc promotes amide formation, whereas n Bu 4 NPO 4 H 2 directs the reaction toward ketone synthesis. This approach offers a versatile and practical route to access amides and ketones from readily available alcohol feedstocks.

Source: JACS Au

DOI: 10.1021/jacsau.5c01148

Authors: Pin Xu, Cong Ma

Institution: Hong Kong Polytechnic University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,500

Funders: Research Grants Council, University Grants Committee, Hong Kong Polytechnic University