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Relationship between aerobic fitness and adipose tissue insulin resistance

Year: 2025

Type: article

Abstract: Greater degrees of aerobic fitness are associated with greater insulin-mediated muscle glucose uptake. Insulin regulates adipose tissue lipolysis, whether aerobic fitness affects insulin's ability to regulate lipolysis is unknown. We found that greater fitness is associated with improved adipose tissue insulin responsiveness independent of age, sex, BMI, visceral adipose tissue, body fat (kg), percent body fat, and adipocyte size. This suggests that exercise, if it improves fitness, may improve both adipose tissue and muscle function.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00327.2025

Authors: Arunima Sharma, Kelli A. Lytle, Michael D. Jensen

Institutions: Mayo Clinic, Advocate Illinois Masonic Medical Center

Language: English

Topic: Adipose Tissue and Metabolism

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institutes of Health