Work

Antimicrobial resistance in blood culture proven sepsis in outborn and inborn neonates

Year: 2025

Type: article

Abstract: BACKGROUND: Neonatal sepsis is a major cause of mortality and morbidity, representing a critical emergency that demands swift diagnosis and intervention. Recent trend shows increasing resistance to commonly used antibiotics. AIMS AND OBJECTIVES: To study the antimicrobial resistance pattern in blood culture positive neonatal sepsis in outborn and inborn neonates and to compare the clinical profile in neonates with proven sepsis. METHODS: Bacterial cultures of the blood samples received from neonates with suspected sepsis was performed and antimicrobial susceptibility testing of blood culture positive neonates was done. Antibiotic sensitivity tests were done as per Clinical and Laboratory Standards Institute (CLSI) 2023 guidelines. RESULTS: Of the 100 participants, 34 were early onset neonatal sepsis and 66 were late onset neonatal sepsis. 35 % of the delivery were vaginal whereas 65 % of the deliveries were by Caesarean section. 17 % of the total neonates delivered had to undergo neonatal resuscitation and 36 % of the neonates had birth asphyxia. The most commonly isolated organisms were Coagulase-negative Staphylococcus species (CoNS) (30 %) followed by Klebsiella pneumoniae (21 %) and Acinetobacter baumannii complex (20 %). 45.1 % were Extended Spectrum beta lactamase (ESBL) producers and 58 % were AmpC beta lactamases producers. Case fatality rate was highest with Klebsiella pneumoniae i.e. 34.6 % followed by Acinetobacter baumannii complex i.e. 23.07 %. CONCLUSION: Increase in antibiotic resistance organisms can lead to an increase in the neonatal case fatality rate (CFR), so regular surveillance is needed. Comparison between the resistance profile between inborn and outborn neonates provides an insight into the difference in the variety of organisms isolated and also the difference in resistance shown by community acquired and hospital acquired organisms.

Source: Indian Journal of Medical Microbiology

DOI: 10.1016/j.ijmmb.2025.101023

Authors: Alisha Mahajan, Varsha Gupta, Suksham Jain

Institution: Government Medical College and Hospital

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,210