Work

Identification and response to a putatively hypervirulent, carbapenem-resistant Klebsiella pneumoniae ST395 hospital outbreak in the UK

Year: 2025

Type: article

Abstract: Here, we describe a putatively hypervirulent, carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) outbreak. Nanopore sequencing guided the infection prevention and control (IPC) responses during the outbreak. Twelve patients were identified as either being colonized and/or having clinical infections with the putative hv-CRKP, with an all-cause mortality within 6 months of 36%. Multiple IPC responses were put in place, with enhanced cleaning of the environment being the key intervention to halt the outbreak. All isolates were ST395 and contained at least one bla NDM carbapenemase gene, along with a variable array of other antimicrobial resistance and virulence genes, due to a rapidly evolving set of plasmids.

Source: Microbial Genomics

DOI: 10.1099/mgen.0.001571